The scianna system consists of seven antigens, including a pair of antithetical antigens, the high and low frequency antigens sc1 and sc2. Sc3 is only absent only from cells of the scianna null phenotype. Description the p antigen, globoside4 gb4, is a prominent glycosphingolipid on human erythrocytes summary by okajima et al. The junior blood group system or jr is a human blood group defined by the presence or absence of the jra antigen, a highfrequency antigen that is found on the red blood cells of most individuals. System name system symbol gene names number of antigens chromosomal location cd numbers. O group is the most frequent in abo blood group system followed by a blood group. Functions of blood groups the structures of the different blood group systems and their. The abo blood group system consists of 4 types of blood group a, b, ab, and o and is mainly based on the antigens and antibodies on red blood cells and in the plasma.
Scianna antigens including rd are expressed by ermap. The scianna system consists of seven antigens, including a pair of antithetical antigens, the high and low frequency antigens sc1 and sc2 gly57arg, an antigen of low frequency sc4, and four antigens of very high frequency. Two high prevalence antigens sc1 and sc3 and two low prevalence sc2 and sc4 radin specify the scianna blood group system. It is second only to abo in importance in blood transfusion and is well known as a primary cause of hemolytic disease of the fetus and newborn hdfn.
This chapter discusses the scianna blood group system. Blood group systems page 4 yt antigens are carried on acetylcholinesterase. Flegel the scianna system was named in 1974 when it was appreciated that two antibodies described in 1962 in fact identified antithetical antigens. Immunohematology reference laboratory a guide to services. Duffy blood group system, classification of human blood based on the presence of glycoproteins known as fy antigens on the surface of red blood cells, endothelial cells cells lining the inner surface of blood vessels, and epithelial cells in the alveoli of the lungs and in the collecting tubules of the kidneys. The authors suggest that the blood group antigens currently known as sm and bua be renamed sc 1 and sc 2 respectively, that the blood group system which they comprise be called scianna and the locus controlling their production sc. N2 the scianna system was named in 1974 when it was appreciated that two antibodies described in 1962 in fact identified antithetical antigens. Polymorphisms in this gene are responsible for the scianna radin blood group system. The antigen is expressed on erythrocytes of about 92% of caucasians but the level of expression of mer2 varies among individuals.
The results from this mutation detection are not intended for the diagnosis of sickle cell disease. Both proteins are encoded by the same gene but arise through an alternative use of two aug initiator codons, at positions 1 and 66 of the mrna sequence. The third edition of the blood group antigen factsbook has been completely revised, updated and expanded to cover all 33 blood group systems. The very rare null phenotype is characterised by the absence of sc1, sc2 and sc3. Jkb was found in 1953 by plaut the antigens were independent of other known blood groups. Blood group systems blood type hematology free 30day. Proprietary laboratory analyses february 2020 panel. Lutheran blood group system, classification of human blood based on the presence of substances called lutheran antigens on the surfaces of red blood cells.
Mns p familial blood group system found in few families kell. What are blood group systems currently there are 345 blood group antigens. Antiyta antiytb xg blood group system antixga scianna blood group system isbt 0. The antigens of the scianna blood group system are carried by the ermap protein. Blood group antibodies and their significance in transfusion medicine joyce poole and geoff daniels the discovery of almost universally present naturally occurring antibodies in blood plasma led to the discovery of the abo blood group system which remains, more than 100 years later, the most important and clinically significant of all blood. There are three antigens in the abo blood group system, a, b and h. Yt blood group system, also called cartwright blood group system, classification of human blood based on the presence of molecules known as yt antigens on the surface of red blood cells. Diego, colton, and scianna blood group systems in human genomic dna. There are 19 known lutheran antigens, all of which arise from variations in a gene called bcam basal cell adhesion molecule. The first is sc1, a high frequency antigen found in greater than 99 % of most populations. Test aborh blood group sample requirements one 5 7ml edta whole blood purple or pink top tube less than. This blood group system is considered the most important, because of the high risk of a severe haemolytic transfusion reaction if abo incompatible blood is transfused. In human blood transfusions it is the most important of the 36 different blood type or group classification systems currently recognized. A mismatch very rare in modern medicine in this, or any other serotype, can cause a potentially fatal adverse reaction after a.
Mar 01, 2018 the lutheran blood group system bgs consists of a large number of antigens, 24 being recognised by the international society of blood transfusion at the time of writing, and is also of interest in terms of the various backgrounds to the apparent luab phenotypes. Table 62 gives information on the blood group systems other than the nine major systems. Blood groups introduction classical abo blood grouping system rh blood grouping system clinical applications of blood groups. Clinical tests 1 available molecular genetics tests. Blood group system scianna abbreviation sc isbt number 0. Scianna blood group system human blood groups wiley online.
Other members of the scianna blood group system include sc3 nason et al. Flegel the scianna system was named in 1974 when it was appreciated. System name system symbol gene names chromosomal location cd numbers 001 abo abo abo 9q34. Human blood groups is a comprehensive and fully referenced text covering scientific and clinical aspects of red cell surface antigens, including. Know the different types of blood transfusions and their complications transfusion reactions. Homozygosity for a pvu ii polymorphism in the estrogen receptor er.
System name system symbol gene names chromosomal location cd numbers 021 cromer crom cd55 1q32. The duffy blood group system the biomedical scientist. The rh blood group system connie westhoff t he rh blood group system is one of the most polymorphic and antigenic blood group systems. Two transcript variants encoding the same protein have been found for this gene. Note that h antigen is in a separate system, h blood group system 018, and is not part of the abo system. Erythroid membraneassociated protein is a protein that in humans is responsible for the scianna blood group system, and is encoded by the ermap gene. The abo gene is located on chromosome 9 and has three alleles, a, b and o. This blood group system was discovered in 1962 when a high frequency antigen was. Other blood group systems, collections, and series. The scianna blood group encompasses the highfrequency antigens sc1. Scianna blood group system 344 sc1 antigen 347 sc2 antigen 348 sc3 antigen 349 sc4 antigen 351 dombrock blood group system 353 doa antigen 356 dob antigen 357 gya antigen 359 hy antigen 360 joa antigen 362 colton blood group system 364 coa antigen 367 cob antigen 368 co3 antigen 369 landsteinerwiener blood group. Reid original report application of realtime pcr and melting curve analysis in rapid diego blood group. Scianna blood group system isbt 0 antisc1 antisc2 dombrock blood group system antidoa antidob antigya antihy antijoa colton blood group system anticoa. The yt blood group is named after cartwright, the person in whom antibodies.
The yt antigens, yta and ytb, were discovered in 1956 and 1964, respectively. Scianna blood group system human blood groups wiley. There are three antigens within the scianna blood group system recognized by the international society of blood transfusion isbt working party on terminology for red cell surface antigens. Blood group systems page 1 start with listings with each line having hyperlink to full section in the rest of this document. The term human blood group systems is defined by international society of blood transfusion as systems in the human species where cellsurface antigensin particular, those on blood cellsare controlled at a single gene locus or by two or more very closely linked homologous genes with little or no observable recombination between them, and include the common abo and rh rhesus antigen. Hueroye k1, chaudhuri a, velliquette rw, fetics s, thomas r, balk m, wagner ff, flegel wa, reid me.
Know the abo and rh systems for blood typing and their clinical significance. A new rbc alloantibody was detected in her serum, reacted with her husbands rbcs. Every blood group system has gene or genes differ than the other systems. Table of blood group systems international society of blood. The scianna blood group system was originally represented by 2 blood group antigens. Johnson 58 case report possible suppression of fetal erythropoiesis by the kell blood group antibody antikpa m. Scianna antigens including rd are expressed by ermap blood. We formally proved that the lowfrequency rd antigen belongs to the scianna blood group system, because it is expressed by a variant ermap protein.
The scianna blood group encompasses the highfrequency antigens. The yt antigens, yt a and yt b, were discovered in 1956 and 1964, respectively. A number of antigens currently 38 cannot yet be assigned to a system. The third edition of the blood group antigen factsbook has been completely revised, updated and expanded to cover all 33 blood group. Jul 23, 2018 when it comes to learning more about an interesting blood group system bgs, duffy is probably perfect.
The antigens are caused by changes in the erythroid membrane associated protein. The lutheran blood group system the biomedical scientist. Scianna was the last previously serologically defined, proteinbased blood group system to be characterized at the molecular level, marking the end of an era in immunohematology. Limitations new mutations that inactivate gene expression or new variant. Blood group systems free download as powerpoint presentation. Jan 15, 2003 the antigens of the scianna blood group system are carried by the ermap protein. The yt blood group is named after cartwright, the person in whom antibodies to the yt antigens were first discovered. The blood group antigen factsbook winner of a 20 highly commended bma medical book award for internal medicine has been an essential resource in the hematology, transfusion and immunogenetics fields since its first publication in the late 1990s. The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. There are 36 blood group systems comprising more than 316 different rbc antigens.
The lutheran bgs is also incorrectly named, as will be explained shortly. Gerbich blood group system isbt 020 the antigens for the gerbich blood group system reside on glycophorin c gpc or glycophorin d gpd glycoproteins. During the blood transfusion, the two most important group systems examined are the abosystem and the rhesus system. Collections a blood group system consists of one or more antigens, controlled by a single gene kell or by two rh or three mns very closely linked homologous genes. The terminology, expression, database accession numbers, and the carrier molecule related to the. Some of the blood group systems of interest in transfusion medicine discussed in this chapter are shown diagrammatically in fig.
Meny original report rhcecear encodes a partial c rh4 antigen c. Class notes i and p blood group systems i blood group system ii antigens. Kidd had hemolytic disease of newborn hdn in her son. The protein is named human erythroblast membrane protein hermap. History of kidd blood group system jka was discovered in 1951 by allen. Scianna blood group system 344 sc1 antigen 347 sc2 antigen 348 sc3 antigen 349 sc4 antigen 351 dombrock blood group system 353 doa antigen 356 dob antigen 357 gya antigen 359 hy antigen 360 joa antigen 362 colton blood group system 364 coa antigen 367 cob antigen 368 co3 antigen 369 landsteinerwiener blood group system 372 lwa antigen 375. Blood group system an overview sciencedirect topics. Pdf the scianna system was named in 1974 when it was appreciated that two antibodies described in 1962 in fact identified antithetical antigens find. Scianna blood group system scianna blood group system lewis, marion. Blood group antibodies and their significance in transfusion. The very rare null phenotype is characterised by the absence of sc1, sc2 and sc3 the antigens are caused by changes in the erythroid membrane associated protein history. An overview of blood group systems with gene name and chromosome location is shown in table 1. A third amino acid polymorphism his26tyr was frequently observed but located in the signal peptide.
The i antigen is found on almost all adults and is part of the precursor component of the oligosaccharide that forms the a, b, and h antigens. Abo blood group systemabh oligosaccharide antigens,antia and antib,a and b glycosyltransferases,and abo genes f. Sequence analysis of the entire coding region 1 deletionduplication analysis 1 genes see tests for all associated and related genes. Blood group collections blood group collections 200 series consist of sero. This blood group system was discovered in 1962 when a. Wiener, diego, colton, and scianna blood group systems in human genomic dna. The abo blood group system is used to denote the presence of one, both, or neither of the a and b antigens on erythrocytes. Immunohematology, volume 27, number 2, 2011 41 scianna.
735 349 53 1509 77 535 1294 637 685 529 1046 133 155 1221 414 586 1295 1172 770 1079 995 1320 1169 955 64 538 420 416 380 1403 262 516 564 908 580 1340 147 940